2,2-(Dimethyl-d6)butanoic Acid(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro|-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]|-1-naphthalenyl Ester; (+)-Simvastatin-d6; Cholestat-d6; Lipex-d6; Novo-Simvastatin-d6; Simvotin-d6; Sinvacor-d6; Statin-d6; Zocor-d6; Zorced-d6
Deuterated Simvastatin, a competitive inhibitor of HMG-CoA reductase. A deuterated synthetic analog of lovastatin. Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
Synonyms
2,2-(Dimethyl-d6)butanoic Acid(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro -3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl] -1-naphthalenyl Ester; (+)-Simvastatin-d6; Cholestat-d6; Lipex-d6; Novo-Simvastatin-d6; Simvotin-d6; Sinvacor-d6; Statin-d6; Zocor-d6; Zorced-d6
CAS No
1002347-71-8 Unlabeled: 79902-63-9
Molecular Formula
C₂₅H₃₂D₆O₅
Appearance
White to off-white solid
Solubility
Chloroform (Slightly), Methanol (Slightly)
Method for Determining Identity
1H NMR (CDCL3) and Mass Spectrometric Analysis
TLC Conditons
SiO2; Dichloromethane: Methanol: = 9 : 1; Visualized with UV and KMnO4; Single Spot, Rf=0.60
Normalized Intensity
d0=0.10%, d1=0.00%, d2=0.01%, d3=0.00%, d4 =0.17%, d5=0.27%, d6=99.46%,
Elemental Analysis
Calculated: %C:70.72, %H:9.02
Specific Rotation (c=0.1, methanol)
As reported
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt. Hygroscopic, Under Inert Atmosphere.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
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