S1013-86W
CAS Number
12656-09-6Grade
Highly PurifiedMolecular Formula
C71H81N19O18S5Molecular Weight
1648.9EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
4°CSiomycin A (Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin)
Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin
Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Recently, siomycin was discovered to be a potent inhibitor of the oncogenic transcription factor-forkhead box M1, FoxM1 (previously known as HFH-11B, Trident, WIN or MPP2). The reduced transcription activity was reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes – Cdc25B, Survivin and CENPB. In vitro, siomycin was demonstrated to inhibit FoxM1 induced cell growth on soft agar and selectively kill transformed but not normal cells.
Form
Supplied as a white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Studies on Siomycin. I Physicochemical properties of siomycin A, B and C. Ebata, M. et al. J. Antibiot., Ser. A, 1969, 22, 364. 2. Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1. Radhakrishnan et. al. Cancer Res. 2006, 19, 9731.USBio References
No references available