SN-38
7-Ethyl-10-hydroxycamptothecin
A metabolite of Irinotecan, a DNA topoisomerase inhibitor.
Method for Determining Identity
1H NMR Spectroscopic Analysis and Specific Rotation.
TLC Conditions
SiO2; Chloroform; Methanol; NH4OH; 9: 1: 0.3; Visualized with UV (280NM) and AMCS; Rf=0.3
Specific Rotation
-22.6º (c=1, DMSO)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
