Solifenacin Succinate |((1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic acid (3R)-1-azabicyclo-[2.2.2]oct-3-yl ester succinate, (1S, 3’R)-3’quinuclidinyl-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate succinate)
(1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic acid (3R)-1-azabicyclo-[2.2.2]oct-3-yl ester succinate; (1S, 3’R)-3’quinuclidinyl-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate succinate
Muscarinic M3 receptor antagoinst. In treatment of urinary incontinence.
Solubility: Methanol, Ethanol, DMSO
Method for Determining Identity: Proton NMR Spectroscopic Analysis
TLC Conditions: SiO2; Dichloromethane : Methanol : Ammonium Hydroxide (9ml: 1ml: 5 drops). Visualized with UV and AMCS. Single spot (Rf= 0.4).
Specific Rotation: +96.5° (c=1; Ethanol)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Caution: Hygroscopic; store under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
