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S7990 Suberoylanilide Hydroxamic Acid (SAHA, Zolinza, Vorinostat) CAS: 149647-78-9

Specifications
References
CAS Number
149647-78-9
Grade
Highly Purified
Molecular Formula
C14H20N2O3
Molecular Weight
264.32
EU Commodity Code
38220090
UN DOT Shipping
UN3077 PGIII
Shipping Temp
RT
Storage Temp
-20°C
SAHA; N-Hydroxy-N’-phenyloctanediamide; N-Hydroxy-N’-phenyloctanediamide; Zolinza; Suberoylanilide-hydroxamic acid, Vorinostat

A potent, selective, cell permeable histone deacetylase inhibitor (HDAC). Displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs). Induces differentiation in uman breast cancer cells.

Appearance
Supplied as a white to off-white solid
Purity
~90% (HPLC, TLC)
Melting Point
156-158°C
Solubility
DMSO, Ethanol
TLC Conditions
SiO2; Chloroform: Methanol: Water: Acetic Acid; 75: 25: 2: 2; Visualized with UV and by exposure to iodine vapor.
Calculated
C: 63.62%, H: 7.63%, N: 10.60%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Purity
~90% (HPLC, TLC)
Form
Supplied as a white to off-white solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
Hancock M.K., et al. 2015. A Facile Method for Simultaneously Measuring Neuronal Cell Viability and Neurite Outgrowth. Current Chemical Genomics and Translational Medicine. 9: 6-16.
USBio References
US Biological application reference: Hancock M.K., et al. 2015. A Facile Method for Simultaneously Measuring Neuronal Cell Viability and Neurite Outgrowth. Current Chemical Genomics and Translational Medicine. 9: 6-16. http://benthamopen.com/contents/pdf/CCGTM/CCGTM-9-6.pdf.
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