Tetradecylthioacetic Acid
TTA; 1-Mono(carboxymethylthio)tetradecane
TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induced insulin resistance and adiposity in Wistar rats. Activates rodent PPAR’s with rank order PPARα>PPARδ>PPARγ.
Synonyms
TTA; 1-Mono(carboxymethylthio)tetradecane
Molecular Formula
C16H32O2S
Solubility
Dichloromethane (Slightly), DMSO (Slightly)
Method for Determining Identity
Proton NMR Spectroscopic Analysis and Mass Spectrometric Analysis
TLC Conditions
SiO2; Dichloromethane: Methanol: Acetic Acid; 9.5ml: 0.5ml: 10drops; Visualized with UV and AMCS; Single spot Rf=0.65.
Appearance
Supplied as a white solid.
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
