5-Methyl-2,4(1H,3H)-pyrimidinedione; NSC 14705; NSC 1686634; 4-Hydroxy-5-methylyrimidin-2(1H)-one; 5-Methyluracil; USP Zidovudine Related Compound C; Zidovudine EP Impurity C
Thymine is a nitrogenous base component in the nucleic acid of DNA.
Synonyms
5-Methyl-2,4(1H,3H)-pyrimidinedione; NSC 14705; NSC 1686634; 4-Hydroxy-5-methylyrimidin-2(1H)-one; 5-Methyluracil; USP Zidovudine Related Compound C; Zidovudine EP Impurity C
CAS Number
65-71-4
Molecular Formula
C₅H₆N₂O₂
Molecular Weight
126.12
Appearance
Supplied as a white to off white powder
Purity (HPLC)
≥99%
Solubility
Clear, colorless to very faint yellow solution. DMSO (Slightly), Methanol (Slightly, Heated)
UV-Vis Spectrum
EMM=7.65 to 8.00 @ 265nm, pH 7.0
Loss on Drying
≤5%
Loss on Drying
≤0.5%
Residue on ignition
≤0.2%
Heavy Metals
≤0.001%
Storage and Stability
Store at RT. Stable for 12 months after receipt.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Purity
≥99% (HPLC)
Form
Supplied as a white to off white powder
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
Keum, Y., et al.: App. Microbiol. Biotechnol., 80, 863 (2008). Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009). Lanevskij, K., et al.: J. Pharm. Sci., 98, 122 (2009); Rajendar, B., et al.: Bioorg. Med. Chem., 17, 351 (2009). Meltzer PC, Liang AY, Matsudaira P, J. Org. Chem. 1995, Vol60, No13, p4305