Tolcapone ((3,4-Dihydroxy-5-nitro-phenyl)(4-methylphenyl)methanone, Ro-40-7592, Tasmar)
(3,4-Dihydroxy-5-nitro-phenyl)(4-methylphenyl)methanone; Ro-40-7592; Tasmar
Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian.
Method for Determining Identity
Proton NMR Spectroscopic Analysis
TLC Conditions
SiO2; Hexane: Methanol: Ethyl acetate; 5:5:2; Visualized with UV and KMnO4 Single spot; Rf=0.8
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Toxicity and Hazards
Due to the potential danger associated with the use of some of United States Biological biochemicals, all products should be handled by qualified personnel only, trained in laboratory procedures, and familiar with potential hazards. Information is not available on the possible hazards of many experimental compounds. The absence of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper handling of any and all chemicals lies with the user. All goods sold by United States Biological carry the condition that liability for any injury, loss or damage whatsoever to persons or real property resulting from the handling of the said goods lies with the user. Acceptance of our goods binds the customer to these terms.
