Coagulation Factor Inhibitor Plasmas (FIPs) are produced from normal human plasmas from which specific factors have been removed by selective affinity immuno-adsorption and an antibody inhibitory to the specific factor is added to provide neutralizing activity. These products can be used as a substitute for plasmas from patients that have developed neutralizing antibodies to coagulation factors. All of these products are intended for research use only.

Availability: FIPs are an economical and reliable alternative to human clinical source material that can be very difficult to obtain. Even samples form extremely rare conditions can be emulated in this way. FIPs are available in volumes ranging from 1ml vials up to bulk volumes.

•Mild: 1-10 BU/mL •Moderate: ≥10-50 BU/mL •Strong: ≥ 50-200 BU/mL The inhibitor potency is measured by standard Bethesda activity assay.

Consistency: Using antibodies of known neutralizing activity and factor-deficient plasma, much greater control of potency between lots is achieved.

Safety: FIPs are made from normal plasma tested at source and found negative for HCV, HIV and HBV. In contrast, clinically derived samples are inherently high risk samples.

Custom Specifications: For special applications, FIPs can be produced to specific potencies in any volume range. Please inquire.