Technical Data

464725
Purity
≥99%
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
Rimacalib
SMP 114; N-[3-[(1S)-1-(2-Fluoro[1,1'-biphenyl]-4-yl)ethyl]-5-isoxazolyl]-4-morpholinecarboximidamide

Rimacalib, a inhibitor of CaMKII, inhibits VEGF expression in human acute monocytic leukemia cell and SF macrophage obtained from patient with rheumatoid arthritis. This effect may contribute to the anti-arthritic effects of Rimacalib. The IC50s of Rimacalib are ~1uM for CaMKIIα to ~30uM for CaMKIIγ.

Synonyms
SMP 114; N-[3-[(1S)-1-(2-Fluoro[1,1'-biphenyl]-4-yl)ethyl]-5-isoxazolyl]-4-morpholinecarboximidamide
CAS No
215174-50-8 HCl Salt: 215174-78-0
Molecular Formula
C₂₂H₂₃FN₄O₂
Molecular Weight
394.44
Appearance
Supplied as a off-white to pale orange solid
Purity
≥99%
Melting Point
>56°C (dec.)
Solubility
Chloroform (Slightly), Methanol (Slightly), DMSO (125mg/ml)
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Westra, Johanna., et al.: BMC Musculoskelet Disord.,11 ,  No pp. given. (2010)|2. Neef S, et al. Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability. Basic Res Cardiol. 2017 Jul;112(4):45.
USBio References
No references available
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