Ribavirin 5’-Triphosphate Trisodium Salt

020637

CAS Number

63142-71-2

Grade

Highly Purified

Molecular Formula

C8H15N4O14P3 (free acid)

Molecular Weight

483.98

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Ribavirin 5’-Triphosphate Trisodium Salt

1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-triphosphate, Sodium salt; [[(2R,3S,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

A metabolite of Ribavirin.

Concentration

10-11mM

Synonyms

1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-triphosphate, Sodium salt

CAS No

63142-71-2

Molecular Formula

C8H15N4O14P3 (free acid)

Molecular Weight

483.98 (free acid)

Appearance

White to off-white solid

Purity

≥95% (HPLC)

Spectroscopic Properties

λmax 230 nm, ε 3.6 L mmol-1 cm-1 (Tris-HCl pH 7.5)

7.5 ±0.5

Storage and Stability

Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References

Allen, L.B., et al.: J. Med. Chem., 21, 742 (1978), Zimmerman, T., et al.: Biochem. Pharmacol., 27, 709|Kiso et al. (2010) T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proc. Natl. Acad. Sci. USA. 107 (2):882.||Maag et al. (2001) Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J. Biol. Chem. 276 (49):46094.||Lanford et al. (2001) Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J. Virol. 75 (17):8074.||Crotty et al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat. Med. 6 (12):1375.||Ulrich et al. (2000) Towards the engineering of an orthogonal protein kinase/nucleotide triphosphate pair. Tetrahedron 56 (48):9495.||Hong et al. (1999) Direct antiviral activity of ribavirin: Hepatitis C virus NS5B polymerase incorporates ribavirin triphosphate into nascent RNA products. Hepatology 30 (4):773 Part 2 Suppl. S.

USBio References

No references available

Technical Data

020637

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

Ribavirin 5’-Triphosphate Trisodium Salt

1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-triphosphate, Sodium salt; [[(2R,3S,4R,5R)-5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

References

USBio References