044440
CAS Number
949004-12-0Grade
Highly PurifiedMolecular Formula
C27H42O3Molecular Weight
414.6EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°C(25S)-delta7-Dafachronic acid
UPF-1404; (5α,25S)-3-oxo-cholest-7-en-26-oic acid
Ligand of DAF-12, an orphan nuclear receptor, that regulates dauer diapause, reproductive development, fat metabolism, and life span (life cycle) in parasitic nematodes. Sterol-derived hormone. Blocks formation of infective larvae in several parasitic nematodes. Inhibits the dauer-promoting activity of DAF-12. Supports the reproductive development.
Synonyms
UPF-1404; (5α,25S)-3-oxo-cholest-7-en-26-oic acid
Molecular Formula
C27H42O3
Appearance
White to off-white solid
Solubility
Highly soluble in DMSO. Soluble in ethanol or methanol. Only slightly soluble in water, dichloromethane or acetone
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans: D.L. Motola, et al.; Cell 124, 1209 (2006). 2. A Potential Biochemical Mechanism Underlying the Influence of Sterol Deprivation Stress on Caenorhabditis elegans: M.C. Cheong, et al.; JBC 286, 7248 (2011) . 3. Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan: K.J. Dumas, et al.; Dev. Biol. 340, 605 (2010). 4. A Conserved Endocrine Mechanism Controls the Formation of Dauer and Infective Larvae in Nematodes: A. Ogawa, et al.; Curr. Biol. 19, 67 (2009). 5. Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes: Z. Wang, et al.; PNAS 106, 9138 (2009). 6. Indicted: Worms Caught using Steroids: R.B. Beckstead & C.S. Thummel; Cell 124, 1137 (2006) Review.USBio References
No references available