Jagged-1 (Human):Fc (Human), Recombinant (Protein Jagged-1, hJ1, CD339, JAG1)
Protein Jagged-1, hJ1, CD339, JAG1
Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).
Recombinant protein corresponding to aa1-1067 from human Jagged-1 fused at the C-terminus to the Fc portion of human IgG1, expressed in HEK 293 cells. Swiss/UniProt Accession: P78504
Biological Activity
Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, HEK293 cells
Form
Supplied as a 0.2um-filtered solution in PBS, pH 7.2.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
