Technical Data

293030
CAS Number
7226-39-3
Grade
Highly Purified
MDL Number
MFCD00061625
Molecular Formula
C6H11FO5
Molecular Weight
182.15
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
2-Deoxy-2-fluoro-D-galactose
3-Fluoro-6-hydroxymethyl-tetrahydro-pyran-2,4,5-triol

2-Deoxy-2-fluoro-D-galactose, also called 3-fluoro-6-hydroxymethyl-tetrahydro-pyran-2,4,5-triol, can be added to the medium of primary cultured rat hepatocytes to inhibit N-glycosylation of proteins. Immunoglobulin G (IgG) is the most common antibody found in blood and 2-deoxy-2-fluoro-D-galactose modifies the galactosylation of the N-linked glycan in the IgG-Fc receptor.  

Synonyms
3-Fluoro-6-hydroxymethyl-tetrahydro-pyran-2,4,5-triol
CAS No
7226-39-3
Molecular Formula
C6H11FO5
Molecular Weight
182.15
Purity (HPLC)
≥97%
Appearance
White to off-white powder
Specific Optical Rotation [alpha]D c=0.5, water, 24hrs)
89 to 95º
1H-NMR Spectrum
Conforms to reference
Storage and Stability
Store at -20ºC. Stable for 12 months after receipt.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Loch et al (1991). 2-Deoxy-2-fluoro-D-galactose protein N-glycosylation. FEBS Letters, 294:217-220.2. Dekkers et al (2016). Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans. Scientific Reports, 6: 36964. 3. Gross et al (1992). Inhibition of protein N-glycosylation by 2-deoxy-2-fluoro-D-galactose. Biochemical Journal, 285(3): 821-826.
USBio References
No references available
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