Technical Data

294059
CAS Number
31528-44-6
Grade
Highly Purified
Molecular Formula
C₂₃H₂₈O₁₂
Molecular Weight
496.46
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
Mycophenolic Acid b-D-Glucuronide
5-[(2E)-5-Carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl β-D-Glucopyranosiduronic Acid;Mycophenolic Acid Glucosiduronate; Mycophenolic Acid Glucuronide; MPAG

Mycophenolic acid b-D-glucuronide is a metabolite of mycophenolic acid, which is an immunosuppressant drug. The glucuronide form of mycophenolic acid is the main form found in human serum. Mycophenolic acid b-D-glucuronide has been shown to have a concentration–time curve that has a higher peak at about 3 hours and lower troughs than those for mycophenolic acid. It has also been shown to have similar effects on autoimmune diseases as its parent compound, but with fewer side effects. Mycophenolic acid b-D-glucuronide can be detected by high performance liquid chromatography (HPLC). The analytical method for this compound was developed using HPLC methods with detection by fluorescence at 254 nm and has been validated for use in human serum samples.

Synonyms
5-[(2E)-5-Carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl β-D-Glucopyranosiduronic Acid;Mycophenolic Acid Glucosiduronate; Mycophenolic Acid Glucuronide; MPAG
CAS No
31528-44-6
Molecular Formula
C₂₃H₂₈O₁₂
Molecular Weight
496.46
Appearance
White to pale beige solid
Purity
≥98%
Melting Point
96-100°C
Solubility
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Senda, M., et al.: Transplantation, 60, 1143 (1995), Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996), Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999)
USBio References
No references available
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