297079
CAS Number
38243-03-7Grade
Highly PurifiedMolecular Formula
C42H72O13Molecular Weight
785.01EU Commodity Code
38220090Shipping Temp
RTStorage Temp
4°CGinsenoside Rg3 (R-)
12β,20R-dihydroxydammar-24-en-3β-yl-2-O-β-D-glucopyranosyl-β-D-glucopyranoside; 20(R)-Propanaxadiol
20(R)-Ginsenoside Rg3 is a saponin that has been found in P. ginseng and inhibits angiogenesis.1 20(R)-Ginsenoside Rg3 (0.001-1 μM) dose-dependently reduces proliferation, capillary tube branching, and the expression of matrix metalloproteinase-9 (MMP-9) and MMP-2 in human umbilical vein endothelial cells (HUVECs). It reduces tumor cell invasion of MM1 rat hepatoma, B16FE7 mouse melanoma, OC-10 human lung carcinoma, and PSN-1 human pancreatic adenocarcinoma cells in vitro by 89, 73.7, 84.2, and 59.1%, respectively, when used at a concentration of 25 µM.2 However, it does not inhibit the proliferation of MM1 cells when used at concentrations ranging from 1.6 to 64 µM. 20(R)-Ginsenoside Rg3 (20 mg/kg) reduces tumor volume, increases the tumor necrosis rate by approximately 16%, and increases survival in a human Lewis lung carcinoma mouse xenograft model.3 It also reduces the total number of B16-BL6 melanoma cell and 26-M3.1 colon carcinoma cell lung colonies in mice by 27 and 51%, respectively, when administered at a dose of 100 µg.4 Topical administration of 20(R)-ginsenoside Rg3 (0.05% w/v) reduces ear thickness by 47.5% compared with control animals in a mouse model of oxazolone-induced contact dermatitis and reduces expression of COX-2, IL-4, IL-1, IFN, and TNF mRNA by greater than 25%.5
Synonyms
12β,20R-dihydroxydammar-24-en-3β-yl-2-O-β-D-glucopyranosyl-β-D-glucopyranoside; 20(R)-Propanaxadiol
Molecular Formula
C42H72O13
Appearance
White to off-white powder
Solubility
Ethanol (Slightly)
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Yue, P.Y., Wong, D.Y., Wu, P.K., et al. The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem. Pharmacol. 72(4), 437-445 (2006).|2. Shinkai, K., Akedo, H., Mukai, M., et al. Inhibition of in vitro tumor cell invasion by ginsenoside Rg3. Jpn. J. Cancer Res. 87(4), 357-362 (1996).|3. Liu, T.G., Huang, Y., Cui, D.D., et al. Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice. BMC Cancer 9, 250 (2009).|4. Mochizuki, M., Yoo, Y.C., Matsuzawa, K., et al. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. Biol. Pharm. Bull. 18(9), 1197-1202 (1995).|5. Bae, E.A., Han, M.J., Shin, Y.W., et al. Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. Biol. Pharm. Bull. 29(9), 1862-1867 (2006).USBio References
No references available