Technical Data

298310
Grade
Highly Purified
Gene ID
2981
Gene #
GUCA2B
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Uroguanylin, Human, aa1-24 (UGN, GUCA2B)

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

Source
Synthetic human Uroguanylin (aa1-24), circulating form, bicyclic
AA Sequence
FKTLRTIANDDCELCVNVACTGCL
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Synthetic
Purity
~95% (HPLC)
Concentration
Not determined
Form
Supplied as a lyophilized powder. Reconstitute with 0.1% acetic acid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Hess R, Kuhn M, Schulz-Knappe P, Raida M, Fuchs M, Klodt J, Adermann K, Kaever V, Cetin Y,|Forssmann WG (1995). GCAP-II: isolation and characterization of the circulating form of human uroguanylin. FEBS Lett 374(1): 34-38. 2. Klodt J, Kuhn M, Marx UC, Martin S, RÖUsch P, Forssmann W-G, Adermann K (1997). Synthesis, biological activity and isomerism of guanylate cyclase C-activating peptides guanylin and uroguanylin. The Journal of Peptide Research 50(3): 222-230. 3. Marx UC, Klodt J, Meyer M, Gerlach H, Rösch P, Forssmann WG, Adermann K (1998). One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers. The Journal of Peptide Research 52(3): 229-240. 4. Lenz W, Herten M, Gerzer R, Drummer C (1999). Regulation of natriuretic peptide (urodilatin) release in a human kidney cell line. Kidney Int 55(1): 91-99.
USBio References
No references available
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