301857
Grade
Highly PurifiedMolecular Weight
6028.82EU Commodity Code
30021019Shipping Temp
Blue IceStorage Temp
4°CAdrenomedullin, Human
Calcitonin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique group of peptide hormones important for homeostasis in diverse tissues. Calcitonin is essential for calcium balance whereas CGRP and ADM are important for neurotransmission, and cardiovascular and respiratory regulation.
Molecular Weight
~6028.82
Sequence
Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val- Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile- Ser-Pro-Gln-Gly-Tyr-NH2, Disulfide Bridge: Cys16-Cys21
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Form
Supplied as a white powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Wang L, Li C, Chen Y, Dong S, Chen X, Zhou Y. Poly(lactic-co-glycolic) Acid/Nanohydroxyapatite Scaffold Containing Chitosan Microspheres with Adrenomedullin Delivery for Modulation Activity of Osteoblasts and Vascular Endothelial Cells. BioMed Research International. 2013;2013:1-13. 2.Deng, Boya et al., Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillin. Journal of Experimental & Clinical Cancer Research, March 9, 2012 Pérez-Castells, J., Martín-Santamaría, S., Nieto, L., et al, Structure of micelle-bound adrenomedullin: A first step toward the analysis of its interactions with receptors and small molecules. Biopolymers. 2012 Jan;97(1):45-53. doi: 10.1002/bip.21700. Epub 2011 Aug 9. |3.Sackett et al. Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function. Endocrinology. 2008 Jun;149(6):2888-98. 4. Allaker et al. Interaction ofadrenomedullin and calcitonin gene-related peptide with the periodontal pathogen Porphyromonas gingivalis FEMS Immunol Med Microbiol. 2007 Feb;49(1):91-7. 5. Allaker et al. Mechanisms of adrenomedullin antimicrobial action. Peptides. 2006 Apr;27(4):661-6. 6.Zudaire et al. Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis.|Am J Pathol. 2006 Jan;168(1):280-91. 7. Ogawa et al. Neuroendocrine profiling of humans receiving cardiac allografts.J Heart Lung Transplant. 2005 Aug;24(8):1046-54. 8. Linscheid et al. Autocrine/ paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. Endocrinology. 2005 Jun;146(6):2699-708. 9.Yin et al. Adrenomedullin protects against myocardial apoptosis after ischemia/reperfusion through activation of Akt-GSK signaling.|Hypertension. 2004 Jan;43(1):109-16. 10.Kapas et al. Regulation of adrenomedullin secretion in cultured human skin and oral keratinocytes. J Invest Dermatol. 2001 Aug;117(2):353-9. 11.Thomson et al. Autocrine role of adrenomedullin in the human adrenal cortex. J Endocrinol. 2001 Jul;170(1):259-65.|12. Pio et al. Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners. J Biol Chem. 2001 Apr 13;276(15):12292-300.|13. Yousufzai et al. Effects of adrenomedullin on cyclic AMP formation and on relaxation in iris sphincter smooth muscle. Invest Ophthalmol Vis Sci. 1999 Dec;40(13):3245-53. 14.Jougasaki et al. Autocrine role for the endothelin-B receptor in the secretion of adrenomedullin. Hypertension. 1998 Nov;32(5):917-22.|15. Lisy et al. Neutral endopeptidase inhibition potentiates the natriuretic actions of adrenomedullin.|Am J Physiol. 1998 Sep;275(3 Pt 2):F410-4.USBio References
No references available