Technical Data

301888
Grade
Highly Purified
Molecular Weight
3507.97
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
4°C
Atrial Natriuretic Peptide, Pepro, aa26-55, Human (ANP, LANP)

Atrial natriuretic peptide (ANP), atrial natriuretic factor (ANF), atrial natriuretic hormone (ANH), or atriopeptin, is a powerful vasodilator, and a polypeptide hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adipose tissue). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes) in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure.

Source
aa26-55, Human
Molecular Weight
~3507.97
Sequence
Asn-Pro-Met-Tyr-Asn-Ala-Val-Ser-Asn-Ala-Asp-Leu-Met-Asp-Phe-Lys-Asn-Leu-Leu-Asp-His-Leu-Glu -Glu-Lys-Met-Pro-Leu-Glu-Asp
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~95% (HPLC)
Form
Supplied as a white powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1.Skelton WP IV, Skelton M, Vesely DL. Cardiac Hormones are Inhibitors of Wnt-3a in Human Cancer Cells. |Cancer Therapy. 2013; 9:24-29. 2.Vesely et al. Four cardiac hormones eliminate 4-fold more human glioblastoma cells than the green mamba snake peptide Cancer Lett. 2007 Aug 28;254(1):94-101.|3.Vesely et al. Vessel dilator: most potent of the atrial natriuretic peptides in decreasing the number and DNA synthesis of human squamous lung cancer cells. Cancer Lett. 2006 Feb 28;233(2):226-31.|4.Lundberg et al. Natriuretic peptide expression in the heart of the TTR-ANP transgenic mouse-Comparison to the normal heart. Microsc Res Tech. 2005 Oct;68(2):97-106.5. Vesely et al. Five cardiac hormones decrease the number of human small-cell lung cancer cells. Eur J Clin Invest. 2005 Jun;35(6):388-98.|6.Yamamoto et al. Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy. Hypertension. 1996 Dec;28(6):988-94.
USBio References
No references available
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