Technical Data

302519
Grade
Affinity Purified
Specificity
Recognizes KHDRBS2. Species Crossreactivity: human, rat
Gene ID
202559
Gene #
KHDRBS2
Applications
WB
EU Commodity Code
30021010
Shipping Temp
Blue Ice
Storage Temp
-20°C
KHDRBS2 (KH Domain-Containing, RNA-Binding, signal transduction-Associated Protein 2, Sam68-like mammalian Protein 1, SLM-1, hSLM-1, KHDRBS2, SLM1)

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity).

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Wang L., et al. Mol. Biol. Rep. 29:369-375(2002).|Ota T., et al. Nat. Genet. 36:40-45(2004).|Mungall A.J., et al. Nature 425:805-811(2003).|Mural R.J., et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.|Cote J., et al. Mol. Biol. Cell 14:274-287(2003).
USBio References
No references available
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