Technical Data

A2295-10B
Grade
Highly Purified
Conjugate
Biotin
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
Angiotensinogen, Pre (1-14) Renin Substrates (human) (Biotin) (AGT, ANHU, SERPINA8)
Biotin-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn

Angiotensinogen is the precursor molecule, and it is produced mainly in the liver, although other sites have been thought to contribute to local effects of the molecule. Production of the peptide is increased by corticosteroids, oestrogens, thyroid homones, and notably, angiotensin II. In humans, the peptide sequence for angiotensinogen (485 amino acids long) which contains (immediatly after the signal peptide) the 10 amino acid: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu. When blood pressure decreases in the kidneys, they produce an enzyme called renin. Renin acts to cleave the peptide bond between the leucine (Leu) and the valine (Val) residues. The ten amino acid peptide (bold) angiotensin I is created.

Sequence (linear): Biotin-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn
Storage and Stability
Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Synthetic peptide
Purity
~90%. Purified by HPLC.
Form
Supplied as a lyophilized powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
No references available
USBio References
No references available
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Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net