G2006-15
CAS Number
19600-01-2Grade
Highly PurifiedMolecular Formula
C67H120N3O26NaMolecular Weight
1406.7EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CGanglioside GM2, Bovine (Sodium Salt)
GM2, Monosialoganglioside GM2
Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Gangliosides isolated from apoptogenic glioblastoma multiforme (GBM) cells are enriched in ganglioside GM2 compared with nonapoptogenic GBM cells, and ganglioside GM2 induces activated T cell death when used at a concentration of 150ug/ml in vitro. Serum ganglioside GM2 levels are increased in patients with breast cancer or cholangiocarcinoma. Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse models of the disease. Ganglioside GM2 accumulates in the lysosomes of individuals with Tay-Sachs disease and GM2-activator deficiency, as well as in the CNS of patients with and animal models of mucopolysaccharide storage disorders and Niemann-Pick disease types A, C1, and C2.
G2006-15 contains ganglioside GM2 molecular species with primarily C18:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone.
Molecular Formula
C67H120N3O26Na (for stearoyl)
Molecular Weight
1383.7 + 23 (calculated on sphingosine C18:1 and stearic acid)
Solubility
Soluble in chloroform/methanol mix (2:1). Also soluble in water.
Appearance
Supplied as a solid
Storage and Stability
Store lyophilized powder at -20°C under dessicated conditions (protect from moisture). Stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Baek, R.C., Martin, D.R., Cox, N.R., et al. Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff disease. Lipids 44(3), 197-205 (2009).|2. Bisel, B., Pavone, F.S., and Calamai, M. GM1 and GM2 gangliosides: Recent developments. Biomol Concepts 5(1), 87-93 (2014).|3. Walkley, S.U. Secondary accumulation of gangliosides in lysosomal storage disorders. Semin. Cell Dev. Biol. 15(4), 433-444 (2004).|4. Chahlavi, A., Rayman, P., Richmond, A.L., et al. Glioblastomas induce T-lymphocyte death by two distinct pathways involving gangliosides and CD70. Cancer Res. 65(12), 5428-5438 (2005).|5. Li, Q., Sun, M., Yu, M., et al. Gangliosides profiling in serum of breast cancer patient: GM3 as a potential diagnostic biomarker. Glycoconj. J. 36(5), 419-428 (2019).|6. Talabnin, K., Talabnin, C., Kumagai, T., et al. Ganglioside GM2: A potential biomarker for cholangiocarcinoma. J. Int. Med. Res. 48(7), 1-10 (2020).USBio References
No references available