G8569-01
CAS Number
136194-77-9Grade
Highly PurifiedMolecular Formula
C24H18N4OMolecular Weight
378.43EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CGo6976|12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-|5-oxo-5H-indolo[2,3-a]pyrrollo[3,4-c]carbazole
Novel, very potent PKC inhibitor with high selectivity for the A-group of PKC isotypes (a, b and gamma), with IC50 values in the 2-10nM range. Little or no inhibition of the B- and C-groups of PKC isotypes, even at much higher concentrations.
Solubility
Soluble in DMSO.
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Form
Supplied as an off-white to yellow powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Kleinschroth, J., Hartenstein, J., Rudolph, C. and Schächtele, C. "Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C." Bioorg. Med. Chem. Lett. 3:1959-1964 (1993). Martiny-Baron, G., Kazanietz, M.G., Mischak, H., Blumberg, P., Kochs, G., Hug, H., Marme, D. and Schächtele, C. "Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976." J. Biol. Chem. 268:9194-9197 (1993).USBio References
No references available