P4256-29U
Grade
Highly PurifiedMolecular Weight
43EU Commodity Code
38220090Shipping Temp
Dry IceStorage Temp
-70°CPlasminogen Activator Inhibitor Type 1, wild type active, Murine (PAI-1)
Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angoigenisis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation. The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer. PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration. This binding has proven to be an important inhibitor of the activated form of protein C (APC).
Storage and Stability
Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Activity
30-70% active by uPA titration.
Form
Supplied as a liquid in 0.05M sodium acetate, 0.4M sodium chloride, 1mM EDTA, pH 5.0.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Sherman, P.M., et al. (1992) J Biol Chem 267: 7588-7595. 2. McMahon, G.A., et al. (2001) J Biol Chem 276: 33964-33968. 3. Devy, L., et al. (2002) FASEB J 16: 147-154. 4. Schneider, J., et al. (2003) Brit J Canc 88(1): 96-101. 5. Hou, A., et al. (2003) 10(7): 541-544. 6. Rezaie, R., et al. (2001) J Biol Chem 276: 15567-15570. 7. Stegansson, S., et al. (1998) J Biol Chem 273: 6358-6366.USBio References
No references available