Stem Cell Research

United States Biological develops and manufactures growth factors and cytokines for stem cell research applications. Cytokines and growth factors are applied to stem cells for culture expansion or to drive differentiation into specific cell types. The human cell manufacturing system ensures native human glycosylation and other human-specific modifications that can result in better bioactivity and enhanced half-life.

Hematopoietic Differentiation

Cytokines are a group of proteins and polypeptides that organisms use as signaling molecules. Most cytokines are glycoproteins less than 30 kDa in size and bind to specific, high-affinity cell surface receptors. Due to their central role in the immune system, cytokines are involved in a variety of immunological, inflammatory and infectious diseases and widely used in research, diagnostics and therapeutics. Cytokines generally alter the gene expression pattern of the target cell which can lead to changes in the rate of cell proliferation and/or in the state of cell differentiation. Currently, these proteins are predominantly produced in non-human cells (e.g. E coli, SF9, CHO ) and therefore lack authenticity due to the absence of physiologically relevant glycosylation. In addition, a number of important cytokines are not commercially available due to inadequate proteolytic processing, protein folding or other post-translational modifications that do not occur in the non-human cell expression systems. United States Biological has developed an efficient human-cell based technology for scalable production of human cytokines.

Authentic Noggin for Stem Cell Research

Recombinant human cytokines are essential for the expansion and differentiation of human stem cells. As stem cell research continues to advance and findings are translated to the clinic, there is a growing need for recombinant cytokines to support the clinical development of cellular therapies. United States Biological, has developed an efficient human-cell based technology for the scalable production of human cytokines. An expanding range of authentic, tag-free cytokines is available, including difficult-to-express protein members of the TGFß1 superfamily. United States Biological’s authentic cytokines can be used as cost effective, highly preferred reagents for stem cell research and clinical development.

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• Molecular Biology