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029418 Rabbit Anti-Aromatase (Cytochrome P450 19A1, CYPXIX, Cytochrome P-450AROM, Estrogen Synthase, CYP19A1, ARO1, CYAR, CYP19)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P11511
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu
Accession #
NP_000094
Shipping Temp
Blue Ice
Storage Temp
-20°C

Human Aromatase is a membrane-bound enzyme that is localized on the endoplasmic reticulum. While it is found in gonads and adrenal glands where it converts androgens into estrogens in a classical endocrine manner, it is also expressed in various tissues where it regulates local estrogen levels or estrogen/androgen ratios in an intracrine manner. Human Aromatase is known to have two major forms, characterized by one amino acid difference at amino acid position 264 [arginine (264R) and cysteine (264C)]. Abnormal Aromatase hyperactivity is a known cause for Aromatase excess syndrome (AES), which is characterized by excess levels of estrogen, heterosexual precocity in adolescent males and isosexual precocity in adolescent females. On the other hand, Aromatase deficiency (AROD) in Aromatase-deficient (ArKO) mice leads to increased adiposity, an inability to synthesize estrogen, birth defects, and genital-related developmental disorders. It is also reported to play a role in a complex immune-neuro-endocrine network management system in murine cysticercosis.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 0.5ug/ml Optimal dilutions to be determined by the researcher.
Positive Control
Human placenta tissue lysate
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic linear peptide corresponding to human Aromatase (KLH). Species sequence homology: Bovine, chimpanzee, rhesus macaque, porcine and canine (100%), rat and mouse (94%).
Form
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Purity
Purified by affinity chromatography.
Specificity
Recognizes human Aromatase.
References
1. Kagawa, N. (2011). Methods Mol Biol. 705: 109-122. 2. Tiulpakov, A., et al. (2005). J Clin Endocrinol Metab. 90(7):4184-4190. 3. Jones, M.E., et al. (2000). Proc Natl Acad Sci USA. 97(23):12735-12740. 4. Morales-Mondor, J., et al. (2008). Curr Top Med Chem. 8(5):400-407.
USBio References
No references available
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