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You are here:Home » Antibodies » Abs to Enzymes, Cytochrome » Anti -Aromatase (Cytochrome P450 19A1, CYPXIX, Cytochrome P-450AROM, Estrogen Synthase, CYP19A1, ARO1, CYAR, CYP19)

Anti -Aromatase (Cytochrome P450 19A1, CYPXIX, Cytochrome P-450AROM, Estrogen Synthase,
CYP19A1, ARO1, CYAR, CYP19)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Human Aromatase is a membrane-bound enzyme that is localized on the endoplasmic reticulum. While it is found in gonads and adrenal glands where it converts androgens into estrogens in a classical endocrine manner, it is also expressed in various tissues where it regulates local estrogen levels or estrogen/androgen ratios in an intracrine manner. Human Aromatase is known to have two major forms, characterized by one amino acid difference at amino acid position 264 [arginine (264R) and cysteine (264C)]. Abnormal Aromatase hyperactivity is a known cause for Aromatase excess syndrome (AES), which is characterized by excess levels of estrogen, heterosexual precocity in adolescent males and isosexual precocity in adolescent females. On the other hand, Aromatase deficiency (AROD) in Aromatase-deficient (ArKO) mice leads to increased adiposity, an inability to synthesize estrogen, birth defects, and genital-related developmental disorders. It is also reported to play a role in a complex immune-neuro-endocrine network management system in murine cysticercosis.
Catalog #029418
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman placenta tissue lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic linear peptide corresponding to human Aromatase (KLH).
SpecificityRecognizes human Aromatase. Species sequence homology: Bovine, chimpanzee, rhesus macaque, porcine and canine (100%), rat and mouse (94%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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