PKP2, CT

Clone Type

Polyclonal

Host

Rabbit

Source

Human

Swiss Prot

Q99959

Isotype

IgG

Grade

Affinity Purified

Applications

E IHC WB

Crossreactivity

Accession #

NP_004563.2

Gene ID

5318

Gene #

PKP2

Shipping Temp

Blue Ice

Storage Temp

-20°C

PKP2, Plakophilin-2

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.

Applications

Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested.

Recommended Dilutions

Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher.

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunogen

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 838-866 in the C-terminal region of human PKP2.

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity

Purified by Protein A and peptide affinity chromatography.

Specificity

Recognizes human PKP2.

References

1. Fressart, V., et al. Europace 12(6):861-868(2010). 2. Cox, M.G., et al. Circ Arrhythm Electrophysiol 3(2):126-133(2010). 3. Christensen, A.H., et al. Cardiology 115(2):148-154(2010). 4. den Haan, A.D., et al. Circ Cardiovasc Genet 2(5):428-435(2009). 5. Bhuiyan, Z.A., et al. Circ Cardiovasc Genet 2(5):418-427(2009)

USBio References

No references available

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040108 Rabbit Anti-PKP2, CT (PKP2, Plakophilin-2)

Clone Type

Host

Source

Swiss Prot

Isotype

Grade

Applications

Crossreactivity

Accession #

Gene ID

Gene #

Shipping Temp

Storage Temp

PKP2, Plakophilin-2

References

USBio References

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