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DAPT (N-S-phenylglycine tert.butyl ester)
DAPT (N-S-phenylglycine tert.butyl ester)
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| Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42). Reduces Abeta levels in vivo. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). Does not inhibit persenilinase. Notch processing inhibitor. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling. CDK5 activity inhibitor. Apoptosis enhancer. | | | Catalog # | 044723 | | Storage and Stability | Short-term Storage: +4°C | | Long-term Storage: -20°C | | Stable for at least 2 years after receipt when stored at -20°C. | | CAS Number | 208255-80-5 | | Molecular Formula | C23H26F2N2O4 | | Molecular Weight | 432.5 | | Purity | >98% (NMR) | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | N--S-phenylglycine tert.butyl ester |
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