CLEC14A (C-type lectin domain family 14 member A; also EGFR5) is a 51kD (predicted) member of the C-type lectin domain family of proteins. It is a type I transmembrane protein, apparently expressed in brain and about which little is known. Mature human CLEC14A is 469aa in length. It contains a 376aa extracellular region (aa22-397) and a 72aa cytoplasmic domain. The extracellular region shows one C-type lectin like domain (aa32-175) and an EGF-like region (aa245-287). Over aa2-397, human CLEC14A shares 66% and 81ª identity with mouse and canine CLEC14A, respectively.
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