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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E B IH IC

Beta-thromboglobulin ( -thromboglobulin, also called Pro-Platelet basic protein or BTG) is a protein that is stored in alpha-granules of platelets and released in large amounts after platelet activation.[1] It is a type of Chemokine (C-X-C motif) ligand 7.[2]  Beta-Thromboglobulin is a chemoattractant, strongly for fibroblasts and weakly for neutrophils. It is a stimulator of mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis in human fibroblasts.[1] Beta-Thromboglobulin also affects megakaryocyte maturation, and thus helps in regulating platelet production.[1] Levels of Beta-Thromboglobulin is used to index platelet activation. It is measured by ELISA in blood plasma or urine, and often in conjunction with Platelet factor 4)[1] It is elevated in diabetes mellitus.[3]
Catalog #	139412
Applications	Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested.
Recommended Dilution	ELISA: 1:100-200
	Western Blot: 1:100-400
	Immunocytochemistry: 1:100-500 (formalin fixed cells)
	Immunohistochemistry: 1:100-500 (formalin fixed frozen sections)
	Immunohistochemistry: 1:50-200 (paraffin sections)
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone Type	Monoclonal
Clone No	13j16
Host	Mouse
Source	Human
Concentration	500ug/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide, 50% glycerol.
Purity	Purified by immunoaffinity chromatography.
Specificity	Recognizes human Beta-Thromboglobulin (bTG)
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.