Beta-thromboglobulin (β-thromboglobulin, also called Pro-Platelet basic protein or BTG) is a protein that is stored in alpha-granules of platelets and released in large amounts after platelet activation.[1] It is a type of Chemokine (C-X-C motif) ligand 7.[2] Beta-Thromboglobulin is a chemoattractant, strongly for fibroblasts and weakly for neutrophils. It is a stimulator of mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis in human fibroblasts.[1] Beta-Thromboglobulin also affects megakaryocyte maturation, and thus helps in regulating platelet production.[1] Levels of Beta-Thromboglobulin is used to index platelet activation. It is measured by ELISA in blood plasma or urine, and often in conjunction with Platelet factor 4)[1] It is elevated in diabetes mellitus.[3]
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