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Specifications

Clone Host Grade Applications Polyclonal Goat Highly Purified IP

Antithrombin II is a single polypeptide chain glycoprotein (MW 61,000) with a high degree of homology with the alpha-1 antitrypsin. It is a circulating natural anticoagulant acting as a proteinase inhibitor. It is synthesized in the liver and the vascular endothelial cells. In electrophoresis of plasma it migrates in the alpha-1 region and is consumed during coagulation in vivo. Antithrombin III inhibits the action of factors IXa, Xa, XIIa, thombin and kallikrein by forming a stable complex. Heparin acts as a cofactor which greatly increases its inhibitory activities. Normal adult plasma contain an average of 0.15mg antithrombin III per ml. This can vary from 75-128%. A partial deficiency in antithrombin III activity in the plasma (<50%) will result in an increased tendency to recurrent thrombo-enbolism. Several types of congenital deficiency have been reported. Most common type 1 deficiency patients have reduced antithrombin III antigen and activity levels. Heterozygotes have levels of 25-50% of normal values.
Catalog #	168922
Applications	Suitable for use Immunoprecipitation, Immunoelectrophoresis, Radial Immunodiffusion and Double Radial Immunodiffusion. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone Type	Polyclonal
Isotype	IgG
Host	Goat
Source	Human
Concentration	Not determined
Form	Supplied as a lyophilized powder. No preservative added. Reconstitute with 1ml sterile dH2O.
Purity	Highly Purified
Immunogen	Antithrombin III
Specificity	Recognizes human Antithrombin III. Does not react with any other component of human plasma. In double radial immunodiffusion a reaction has been found with Rhesus Monkey.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.