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You are here:Home » Antibodies » Abs to Binding Factors » Anti -HMG1 (HMG1, High Mobility Group 1)

Anti -HMG1 (HMG1, High Mobility Group 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
High mobility group 1 (HMG1) is a 26kD highly con- served non-sequence-specific DNA-binding nuclear protein. Mammalian HMG1 has two homolo-gous DNA- binding domains HMG boxes, A and B (each of 8090 amino-acid residues), linked by a short basic region to an acidic C-terminal domain containing 30 consecutive Asp and Glu residues. HMG1 has been implicated in a number of fundamental biological processes including transcription, replication and recombination, in which it plays a role in manipulating DNA structure by bending, looping, compaction or unwinding, or by direct contacts with distinct cellular proteins. HMG1 can act as a repressor, by interacting with TBP to block pre-initiation complex formation or as an activator, by facilitating the binding of various transcription factors to their cognate DNA sequences. Most recently, it was discovered that HMG1 is a late mediator of delayed endotoxin lethality by activating downstream cytokine release.
Catalog #169533
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:2000-1:5000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
ConcentrationNot determined
FormSupplied as a liquid.
PuritySerum.
ImmunogenPeptide corresponding to a-HMG1.
SpecificityRecognizes HMG1. Reacts with the HMG1 protein in HeLa nu-clear extract
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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