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You are here:Home » Molecular Biology » Growth Factors-BRAK » BRAK, Recombinant, Human (CXCL1, 4C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G) (Small-inducible cytokine B14))

BRAK, Recombinant, Human (CXCL1, 4C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G)
(Small-inducible cytokine B14))


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Human Chemokine (C-X-C motif) ligand 14(hCXCL14),also known as breast and kidney-expressed chemokine (BRAK), MIP-2 gamma, kidney-expressed chemokine (KEC), and B cell and monocyte-activating chemokine (BMAC), is a CXC chemokine constitutively expressed in certain normal tissues but is reduced or absent from many established tumor cell lines and human cancers. CXCL14 is known to be a chemo-attractant for monocyte and dendritic cells. CXCL14 inhibits angiogenesis and exhibits antimicrobial activities. Mature human and mouse CXCL14 differ by only 2 residues.
Catalog #169937
SourceRecombinant protein corresponding to human BRAK, expressed in E. coli.
Molecular Weight~9.4kD
Biological ActivityThe ED50 as determined by its ability to induce calcium flux of prostaglandin E2 treated THP1 human acute monocytic leukemia cells was 1.0-10.0ng/ml.
Endotoxin<0.1ng/ug (1IEU/ug)
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~9.4kD
SourceE. coli
Purity~95% (SDS-PAGE, HPLC)
Concentration~1mg/ml after reconstitution
FormSupplied as a lyophilized powder in 20mM Tris HCl, pH 8.5, 1M NaCl. Reconstitute with H2O not less than 100ug/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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