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You are here:Home » Antibodies » Abs to Enzymes » Anti -Acetyl CoA Carboxylase (ACC1)

Anti -Acetyl CoA Carboxylase (ACC1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IH FC IF
Acetyl-CoA carboxylase (ACC) catalyzes the pivotal step of the fatty acid synthesis pathway. The 265kD ACCa is the predominant isoform in liver, adipocytes and mammary gland, while the 280kD ACCb is the major isoform in skeletal muscle and heart. Phosphorylation by AMPK at Ser79, or by PKA at Ser1200, inhibits the enzymatic activity of ACC. ACC is a potential target of anti-obesity drugs.
Catalog #A0224
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunofluorescence. Other applications not tested.
Recommended DilutionsFlow Cytometry: 1:25
Western Blot: 1:1000
Immunohistochemistry (Paraffin): 1:50. Antigen retrieval with citrate buffer is recommended.
Immunoprecipitation: 1:50
Immunofluorescence (IF-IC): 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by Protein A and peptide affinity chromatography.
ImmunogenSynthetic peptide corresponding to residues surrounding Lys557 of human acetyl CoA carboxylase a1 conjugated to KLH.
MW of Antigen280kD.
SpecificityRecognizes endogenous levels of all isoforms of human acetyl CoA carboxylase protein at ~280kD. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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