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You are here:Home » Biochemicals » Biochem-Antibiotics » Actinomycin D (Streptomyces antibioticus, Dactinomycin, Actinomycin IV, Actinomycin C1)

Actinomycin D (Streptomyces antibioticus, Dactinomycin, Actinomycin IV, Actinomycin C1)

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Specifications

Suitable for use in nucleic acid inhibition. Actinomycin D inhibits the proliferation of cells in a cell-cycle nonspecific way by forming a stable complex with DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It is used in cell culture as a selection agent.
Catalog #A0850
Chemical Name 2-Amino-(N,N)-1-bis(hexadecahydro-6­,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentao­xo-1H-pyrrolo[2,1]-[1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-ox­o-3H-phenoxazine-1,9-dicarboxamide
Purity 95%
Appearance: Orange to red-brown crystaline powder
Identity: Conforms to USP reference
Potency: 900u/mg
Specific Rotation:-292 to -317º
Heavy Metals: <0.001%
Loss on Drying: 5%
RNase:None Detected
DNase: None Detected
Protease: None Detected
Residue on Ignition: 0.1%
Endotoxin: 100EU/mg
Working concentration: 0.01 to 2ug/ml
Solublility: Dimethyl sulfoxide (DMSO) 1mg/ml
Light and moisture sensitive.
CAS Number50-76-0
Molecular FormulaC62H86N12O16
Molecular Weight1255.43
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesStreptomyces antibioticus, Dactinomycin, Actinomycin IV, Actinomycin C1


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