Actinomycin D (Streptomyces antibioticus, Dactinomycin, Actinomycin IV, Actinomycin C1)
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| Suitable for use in nucleic acid inhibition. Actinomycin D inhibits the proliferation of cells in a cell-cycle nonspecific way by forming a stable complex with DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It is used in cell culture as a selection agent. | | | Catalog # | A0850 | | Chemical Name | 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide | | Purity | 95% | | Appearance: Orange to red-brown crystaline powder | | Identity: Conforms to USP reference | | Potency: 900u/mg | | Specific Rotation:-292 to -317º | | Heavy Metals: <0.001% | | Loss on Drying: 5% | | RNase:None Detected | | DNase: None Detected | | Protease: None Detected | | Residue on Ignition: 0.1% | | Endotoxin: 100EU/mg | | Working concentration: 0.01 to 2ug/ml | | Solublility: Dimethyl sulfoxide (DMSO) 1mg/ml | | Light and moisture sensitive. | | CAS Number | 50-76-0 | | Molecular Formula | C62H86N12O16 | | Molecular Weight | 1255.43 | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Streptomyces antibioticus, Dactinomycin, Actinomycin IV, Actinomycin C1 |
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