Anti -Adiponectin Receptor 2 (ADIPOR2, ACDCR2, Adiponectin Receptor Protein 2, FLJ21432,
MGC4640, PAQR2, Progestin and AdipoQ Receptor Family Member II)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH IF |
|
| Acrp30 (adipocyte complement-related protein of 30kD), also known as AdipoQ, APM1, Adiponectin, Gelatin binding protein 28kD/GBP28 or adipocyte most abundant gene transcript) was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, Acrp30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased Acrp30 levels. Acrp30 is proteolytically cleaved at 104 aa to generate the globular Acrp30 (gAcrp30). Administration of gAcrp30 into mice fed a diet high in fat and sugar caused substantial weight loss. A marked reduction in plasma triglycerides, glucose, and free fatty acids was attributed due in part to increased fatty acid oxidation by muscle. Full length Acrp30 was less potent than gAcrp30. | | | Adiponectin receptor 2/ADIPOR2, a 311-aa protein (mouse) with a Mol.wt of 35.4kD and human ADIPOR2 has 299aa which shares 95.2% homology with that of mouse. The ADIPOR2 serves as receptor for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. ADIPOR2 is most abundantly expressed in Liver. | | | Catalog # | A0886-80A | | Applications | Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1-10ug/ml. | | ELISA: 0.5-1ug.ml. A0886-80B; iponectin Receptor 2, Mouse,Control peptide can be used to coat ELISA plates at 1ug/ml. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.1% BSA, 40% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide, 15aa corresponding to near the N-terminus of mouse ADIPOR2 (KLH). | | Specificity | Recognizes mouse ADIPOR2. Species sequence homology: rat, 100%; human, 93%. No significant sequence homology is seen with ADIPOR1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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