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A1210-03 ALAS2, Recombinant, Human, His-Tag, aa136-553 (Aminolevulinate delta-Synthase 2, Delta ALA Synthetase) CAS:

Specifications
References
Grade
Purified
Swiss Prot
P22557
Accession Number
NM_000032
Molecular Weight
46
EU Commodity Code
30021019
Shipping Temp
Dry Ice
Storage Temp
-70°C

ALAS2 specifies an erythroid-specific mitochondrially located enzyme. It catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

Source
Recombinant protein corresponding to human ALAS, aa136-553, with N-terminal His tag, expressed in E. coli.
Molecular Weight
~46kD
Applications
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Source
E. coli
Purity
≥90%
Concentration
As reported
Form
Supplied as a liquid in 25mM Tris-HCl, pH 8.0, 100mM NaCl, 0.05% Tween-20, 20% glycerol, 3mM DTT, 20uM pyridoxal 5' phosphate monohydrate.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Lee, P.L. et al., Blood Cells Mol. Dis. 36 (2), 292-297 (2006). 2. Astner, I. et al., EMBO J. 24 (18), 3166-3177 (2005).
USBio References
No references available
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