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You are here:Home » Molecular Biology » MB-Enzymes, Synthetase » ALAS2, Recombinant, Human (Aminolevulinate delta-Synthase 2, Delta ALA Synthetase)

ALAS2, Recombinant, Human (Aminolevulinate delta-Synthase 2, Delta ALA Synthetase)

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Specifications

ALAS2 specifies an erythroid-specific mitochondrially located enzyme. It catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.
Catalog #A1210-03
SourceRecombinant human ALAS, aa136-553, with N-terminal His tag, expressed in E. coli.
Molecular Weight 46kD
ApplicationsUseful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityAliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
Molecular Weight46kD
SourceE. coli
Purity90%
ConcentrationAs reported
FormSupplied as a liquid in 25mM Tris-HCl, pH 8.0, 100mM NaCl, 0.05% Tween-20, 20% glycerol, 3mM DTT, 20uM pyridoxal 5' phosphate monohydrate.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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