4-ABP has been shown to be a bladder carcinogen in humans and rodents. As well as genetic factors, 4-ABP may also play a role in breast cancer. It is hypothesized that smokers may have higher levels of DNA adducts than non-smokers and that the role of 4-ABP-DNA adducts and their relationship to tobacco exposure may be related to breast tumorigenesis. The antibody has been used to investigate the role of 4-ABP in the study of human breast cancer by measuring 4-ABP-DNA adducts.

Cellular Localization: Nuclear

Suitable for use in Immunofluorescence, ELISA, Immunohistochemistry and Immunocytochemistry. Other applications not tested.

ELISA: 1:50-1:100 Immunohistochemistry: 1:50-1:100 Immunocytochemistry: 1:50-1:100 Immunofluorescence: 1:50-1:100 Optimal dilutions to be determined by the researcher.

May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

4-amino Biphenyl DNA.

Supplied as a liquid (ascites).

Purified by Protein G affinity chromatography.

This antibody is specific for 4-amino Biphenyl DNA. Crossreactivity: All DNAs