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Anti -4-Amino Biphenyl DNA (4-AMBP DNA, 4-Aminobiphenyl DNA)
Anti -4-Amino Biphenyl DNA (4-AMBP DNA, 4-Aminobiphenyl DNA)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E IH IC IF |
|
| 4-amino Biphenyl (4-ABP) is an aromatic amine (arylamine). 4-ABP can be found as a constituent of tobacco smoke, in the form of an environmental carcinogen. It is metabolized by hepatic cytochrome P4501A2 to yield a direct-acting mutagen known as N-hydroxy-aminobiphenyl. Yet, the accumulation of biologically active metabolites is dependent on the activation and detoxification of N-acetylation. | | | Catalog # | A1401 | | 4-ABP has been shown to be a bladder carcinogen in humans and rodents. As well as genetic factors, 4-ABP may also play a role in breast cancer. It is hypothesized that smokers may have higher levels of DNA adducts than non-smokers and that the role of 4-ABP-DNA adducts and their relationship to tobacco exposure may be related to breast tumorigenesis. The antibody has been used to investigate the role of 4-ABP in the study of human breast cancer by measuring 4-ABP-DNA adducts. | | Cellular Localization | Nuclear | | Applications | Suitable for use in Immunofluorescence, ELISA, Immunohistochemistry and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 1:50-1:100 | | Immunohistochemistry: 1:50-1:100 | | Immunocytochemistry: 1:50-1:100 | | Immunofluorescence: 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Monoclonal | | Clone No | 8J250 | | Host | Mouse | | Concentration | ~1mg/ml | | Form | Supplied as a liquid (ascites). | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | 4-amino Biphenyl DNA. | | Specificity | This antibody is specific for 4-amino Biphenyl DNA. Crossreactivity: All DNAs | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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