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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -4-Amino Biphenyl DNA (4-AMBP DNA, 4-Aminobiphenyl DNA)

Anti -4-Amino Biphenyl DNA (4-AMBP DNA, 4-Aminobiphenyl DNA)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH IC IF
4-amino Biphenyl (4-ABP) is an aromatic amine (arylamine). 4-ABP can be found as a constituent of tobacco smoke, in the form of an environmental carcinogen. It is metabolized by hepatic cytochrome P4501A2 to yield a direct-acting mutagen known as N-hydroxy-aminobiphenyl. Yet, the accumulation of biologically active metabolites is dependent on the activation and detoxification of N-acetylation.
Catalog #A1401
4-ABP has been shown to be a bladder carcinogen in humans and rodents. As well as genetic factors, 4-ABP may also play a role in breast cancer. It is hypothesized that smokers may have higher levels of DNA adducts than non-smokers and that the role of 4-ABP-DNA adducts and their relationship to tobacco exposure may be related to breast tumorigenesis. The antibody has been used to investigate the role of 4-ABP in the study of human breast cancer by measuring 4-ABP-DNA adducts.
Cellular Localization Nuclear
ApplicationsSuitable for use in Immunofluorescence, ELISA, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionELISA: 1:50-1:100
Immunohistochemistry: 1:50-1:100
Immunocytochemistry: 1:50-1:100
Immunofluorescence: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No8J250
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid (ascites).
PurityPurified by Protein G affinity chromatography.
Immunogen4-amino Biphenyl DNA.
SpecificityThis antibody is specific for 4-amino Biphenyl DNA. Crossreactivity: All DNAs
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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