Anguinomycin A CAS 111278-01-4

Subscribe to our newsletter!

Welcome | LOG OUT

A2295-11L1 Anguinomycin A (5-Demethyl-leptomycin A, KR 2827A, Antibiotic KR 2827A) CAS: 111278-01-4

Specifications

References

CAS Number

111278-01-4

Grade

Highly Purified

Molecular Formula

C31H44O6

Molecular Weight

512.68

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

5-Demethyl-leptomycin A, KR 2827A, Antibiotic KR 2827A

Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumour activity in mice against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of Leptomycin B, an inhibitor of nuclear export of proteins.

Purity: >95% by HPLC

Solubility: Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO.

Related to: Leptomycin A, Leptomycin B, Kazusamycin A, Kazusamycin B

Source

Streptomyces sp.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells. |Hayakawa Y. et al. J. Antibiot. 1995, 48, 954. 2. New antitumor antibiotics, anguinomycins A and B. Hayakawa Y. et al. J. Antibiot. 1987, 40, 1349.