Anti -Apolipoprotein B (Apo B, ApoB, ApoB Protein, Apolipoprotein B-48, ApoB-48,
Apolipoprotein B-100, ApoB-100, Apo-B-100, FLDB, LDLCQ4)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Highly Purified |
E RIA |
|
| Apolipoprotein B (ApoB) is a large secretory protein with a molecular weight of 550kDa that plays a central role in lipoprotein metabolism. ApoB exists in the plasma in 2 main isoforms, ApoB100 and ApoB48. ApoB100 is synthesized in the liver, and is the major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL), and is absolutely required for their formation. ApoB100 acts as a ligand for LDL receptors in various cells throughout the body, allowing cells to internalise LDL and absorb cholesterol. ApoB48 is expressed in the intestine and is present on chylomicrons and their remnants, and lacks the C-terminal LDL-receptor binding region of ApoB100. Elevated plasma concentrations of ApoB containing lipoproteins are key risk factors for the development of atherosclerosis. | | | Catalog # | A2299-52B | | Applications | Suitable for use in ELISA and RIA. Other applications not tested. | | Recommended Dilutions | Optimal dilutions to be determined by the researcher. | | Hybridoma | P3X63.Ag8.653 myeloma cells with spleen cells from Balb/c mice. | | Recommended secondary antibodies | I1904-06C: IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo | | I1904-06H IgG, H&L (HRP) (X-Adsorbed) Pab Gt xMo | | I1904-14C: IgG, Fc (HRP) Pab Gt xMo | | I1904-19C: IgG, F(ab’)2 (HRP) Pab Gt xMo | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 10B190 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by DEAE chromatography. | | Immunogen | Purified human serum LDL | | Specificity | Recognizes human Apolipoprotein B. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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