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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B

ARC (apoptosis repressor with CARD), also known as nucleolar protein 3. Apoptosis is regulated by molecules containing death domains or caspase recruitment domains (CARD). ARC contains a CARD domain, interacts with caspase-2 and interacts with and inhibits the activity of caspase-8. ARC suppresses apoptosis induced by the cell death receptors Fas, TNFR-1 and DR3 and by the cell death adapters FADD and TRADD. It is highly expressed in heart and skeletal tissue and found in low levels in placenta, kidney, liver and pancreas.
Catalog #	A3325-01E
Applications	Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution	Western Blot: 1:500 ~24kD in HeLa whole cell lysates.
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	As reported
Form	Supplied as a liquid in PBS, 0.02% sodium azide.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide corresponding to amino acids 2-18 of human ARC.
Specificity	Recognizes human ARC (apoptosis repressor with CARD), also known as nucleolar protein 3. Species Crossreactivity: mouse, rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	NUCLEOLAR PROTEIN 3