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You are here:Home » Antibodies » Antibodies-Cancer Markers » Anti -ARF, p14

Anti -ARF, p14


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IF
The INK4a-ARF locus encodes two unrelated proteins both of which function in tumor suppression. p14ARF arrests the cell cycle in a p53-dependent manner. p14ARF binds to mdm2 and promotes the rapid degradation of mdm2 protein. This interaction is mediated by the exon 1b-encoded N-terminal domain of p14ARF and a C-terminal region of mdm2. ARF-mediated mdm2 degradation is associated with mdm2 modification and concurrent p53 stabilization and accumulation. Deletion of the ARF-INK4a locus simultaneously impairs both the INK4a-cyclin D/cdk4-RB and the ARF-mdm2-p53 pathways.
Catalog #A3330-02
Positive Control HeLa cells.
Applications and Suggested DilutionsImmunofluorescence
Immunoprecipitation (Use Protein G)
(Ab 2mg/mg protein lysate)
Western Blotting (Ab 2-4mg/ml for 2hrs at RT)
Cellular Localization Nuclear
Clone TypeMonoclonal
Clone No0.N.479
Form10mM PBS, pH 7.4, with 0.2% BSA and 15mM sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant p14ARF protein.
SpecificityRecognizes human p14ARF. Does not react with mouse and rat.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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