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Anti -BACE2, Asp1 (NT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2, DRAP, Down Region Aspartic Protease, Memapsin)
Anti -BACE2, Asp1 (NT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2, DRAP, Down
Region Aspartic Protease, Memapsin)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor (APP) at b-and g-sites by proteases. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1–4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4–9). BACE2 also cleaves APP at b-site and at a different site within Ab (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and Ab may also contribute to the pathogenesis of Down syndrome (6,7) | | | Catalog # | B0003 | | Applications | Suitable for use in ELISA, Western Blotting. Other applications not tested. | | Recommended Dilution | Western Blotting: 0.5-1ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human heart tissue lysate can be used as positive control. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid, 100ug in 200ul of PBS, 0.02% sodium azide. | | Purity | Immunoaffinity chromatography purified IgG | | Immunogen | Raised against a synthetic peptide (APTPGPGTPAERHADG) corresponding to amino acids 44 to 59 of human BACE2 (4). | | Specificity | Recognizes human BACE2. Species crossreactivity: Mouse and rat. | | | Important Note | This product is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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