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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -BAFF (B cell Activating Factor belonging to TNF Family, BLyS, TALL-1, THANK)

Anti -BAFF (B cell Activating Factor belonging to TNF Family, BLyS, TALL-1, THANK)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified B
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-£eB and c-jun N-terminal kinase.
Catalog #B0003-65B
ApplicationsWestern Blotting: 0.25-1ug/ml
Optimal working dilutions to be determined by researcher.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS with 0.02% sodium azide.
PurityPurified IgG was prepared from whole serum by ion exchange chromatography.
ImmunogenPeptide corresponding to amino acids 254-269 of human BLyS.
SpecificityRecognizes BLyS (also known as BAFF, TALL-1 and THANK), a novel member of the tumor necrosis factor (TNF) superfamily. BLyS (B lymphocyte stimulator) and its receptor TACI/BCMA are involved in the development of autoimmune diseases. BlyS has been shown to activate NFkB and JNK (c-jun N-terminal kinase) and induce apoptosis. Species Crossreactivity: mouse, human, rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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