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You are here:Home » Antibodies » Abs to Hormones, Steroids » Anti -Brain Natriuretic Peptide Pro (proBNP, Natriuretic Peptides B, Gamma-brain Natriuretic Peptide, NPPB)

Anti -Brain Natriuretic Peptide Pro (proBNP, Natriuretic Peptides B, Gamma-brain
Natriuretic Peptide, NPPB)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Human BNP is a 3.5kD, secreted, nonglycosylated peptide that belongs to the natriuretic peptide family. It is the product of ventricular myocytes and bone marrow endothelial cells. BNP is synthesized as a 12kD, 108aa prohormone with a 76aa prosegment and a 32aa mature (BNP) region. Both forms circulate, with the prohormone showing O-linked glycosylation that generates a 25-27kD glycoprotein. Glycosylation is suggested to stabilize the molecule. The proform also tends to noncovalently trimerize. In blood, 1-32 BNP is proteolytically processed into 3-32 BNP, with loss of Ser-Pro at the N-terminus. Human Pro-BNP is 29% and 50% aa identical to mouse and pig Pro-BNP.
Catalog #B2702-01N
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.1mg/ml after reconstitution
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.2mg/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa27-134 from human Pro-BNP expressed in E.coli.
SpecificityRecognizes human Pro-BNP.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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