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You are here:Home » Antibodies » Abs to Peptides » Anti -CD88 (C5aR, C5a Receptor 1, C5aR1, Complement Component 5a Receptor 1)

Anti -CD88 (C5aR, C5a Receptor 1, C5aR1, Complement Component 5a Receptor 1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH FC
The human anaphylatoxin C5a is a 74-residue glycopolypeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a could be demonstrated, rendering this molecule an important mediator of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor (CD88), a seven transmembrane GTP binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The C5a receptor is approximately 45kD.
Catalog #C0012-01D
ApplicationsSuitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:10-1:1000
Immunohistochemistry (frozen and paraffin): 1:10-1:2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J452
HostMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenExtracellular domain of the N-terminus of CD88. Cellular Localization: Integral membrane protein.
SpecificityRecognizes human CD88.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAnaphylatoxin Receptor


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