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You are here:Home » Antibodies » Abs to Kelch-like Proteins » Anti -C3IP1 (KLHL12, C3IP1, DKIR, CUL3-interacting protein 1, Kelch-like 12)

Anti -C3IP1 (KLHL12, C3IP1, DKIR, CUL3-interacting protein 1, Kelch-like 12)

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Affinity Purified B IH IC
Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3. Component of an ubiquitin-protein E3 ligase complex which includes at least CUL3 and KLHL12. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A.
Catalog #C0045-61A
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: Predicted molecular weight 68kD.
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgY
HostChicken
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2. No preservative.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: KHAKKEREES LPNLLQYVRM PLLTPRYITD VIDAEPFIRC SLQCRDLVDE AKKFHLRPEL RSQMQGPRTR ARLGANEVLL VVGGFGSQQS PIDVVEKYDP KTQEWSFLPS ITRKRRYVAS VSLHDRIYVI GGYDGRSRLS SVECLDYTAD EDGVWYSVAP MNVRRGLAGA TTLGDMIYVS GGFDGSRRHT SMERYDPNID, corresponding to amino acids 205-404 of Human C3IP1.
SpecificitySpecies Crossreactivity: Crossreacts with Human, Mouse and Rat. Expected to crossreact with Xenopus laevis (92% identity with immunogen) due to sequence homology.Not yet tested in other species.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesKLHL12, C3IP1, DKIR, CUL3-interacting protein 1, Kelch-like 12


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