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You are here:Home » Antibodies » Abs to Ion Channel » Anti -CACNB3 (Voltage-dependent L-type Calcium Channel Subunit beta-3, CAB3, Calcium Channel Voltage-dependent Subunit beta 3, CACNLB3)

Anti -CACNB3 (Voltage-dependent L-type Calcium Channel Subunit beta-3, CAB3, Calcium
Channel Voltage-dependent Subunit beta 3, CACNLB3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
Catalog #C0104-80
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:200-1:300 on Rat brain membranes using ECL.Further dilutions can be made using a carrier protein such as BSA (1-3%).
Optimal dilutions to be determined by the researcher.
Control Antigen IncludedC0104-80A: Reconstitute with 100ul of sterile dH2O. For negative control, preincubate 1ug of purified peptide with 1ug of antibody for 1hr at RT.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
Concentration~0.3mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, pH 7.4, 1% BSA, 5% sucrose, 0.025% sodium azide. Reconstitute with 50ul sterile dH2O. Further dilutions should be made using a carrier protein such as BSA (1-3%).
PurityPurified
ImmunogenSynthetic peptide corresponding to aa463-477 of rabbit Ca-beta 3, (Accession number P54286). Species Sequence Homology
SpecificityRecognizes rat Ca-beta 3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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