Calcium/calmodulin-dependent protein kinase II a (CaMKIIa) is a 50kD member of the CaMKII family of serine-threonine kinases that transduce Ca2+ signals to several target proteins, including ion channels and transcription activators. CaMKII is predominantly expressed in two isoforms in the brain: a and b. CaMKII plays an important role in neuronal plasticity and memory formation, and exerts both calcium-calmodulin-dependent and -independent activities. Autophosphorylation of CaMKIIa on threonine 286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state, and is required for various cellular functions including hippocampal long-term potentiation (LTP), special learning, and hippocampus-dependent memory.
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