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Anti -Calmodulin-Dependent Protein Kinase II, alpha, phosphorylated (Thr286) (CAMKII)
Anti -Calmodulin-Dependent Protein Kinase II, alpha, phosphorylated (Thr286) (CAMKII)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Calcium/calmodulin-dependent protein kinase II a (CaMKIIa) is a 50kD member of the CaMKII family of serine-threonine kinases that transduce Ca2+ signals to several target proteins, including ion channels and transcription activators. CaMKII is predominantly expressed in two isoforms in the brain: a and b. CaMKII plays an important role in neuronal plasticity and memory formation, and exerts both calcium-calmodulin-dependent and -independent activities. Autophosphorylation of CaMKIIa on threonine 286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state, and is required for various cellular functions including hippocampal long-term potentiation (LTP), special learning, and hippocampus-dependent memory. | | | Catalog # | C1035-25F1 | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide derived from a region of human CaMKIIa contains threonine 286. Species sequence homology: mouse and rat. | | Specificity | Recognizes Rat CaMKIIa when phosphorylated at Thr286. Species sequence homology: human and mouse (100%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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