Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Calmodulin » Anti -Calmodulin-Dependent Protein Kinase II, alpha, phosphorylated (Thr286) (CAMKII)

Anti -Calmodulin-Dependent Protein Kinase II, alpha, phosphorylated (Thr286) (CAMKII)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Calcium/calmodulin-dependent protein kinase II a (CaMKIIa) is a 50kD member of the CaMKII family of serine-threonine kinases that transduce Ca2+ signals to several target proteins, including ion channels and transcription activators. CaMKII is predominantly expressed in two isoforms in the brain: a and b. CaMKII plays an important role in neuronal plasticity and memory formation, and exerts both calcium-calmodulin-dependent and -independent activities. Autophosphorylation of CaMKIIa on threonine 286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state, and is required for various cellular functions including hippocampal long-term potentiation (LTP), special learning, and hippocampus-dependent memory.
Catalog #C1035-25F1
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide derived from a region of human CaMKIIa contains threonine 286. Species sequence homology: mouse and rat.
SpecificityRecognizes Rat CaMKIIa when phosphorylated at Thr286. Species sequence homology: human and mouse (100%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links