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You are here:Home » Antibodies » Abs to Calnexin » Anti -Calnexin

Anti -Calnexin

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit B IP IC
Calnexin (CNX), an abundant ~90kD molecular chaperone, is a unglycosylated resident ER transmembrane protein. In mammalian cells, calnexin, together with calreticulin (CRT), plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglucosylated glycans (4). Calnexin associates with newly synthesized monomeric glycoproteins and only recognizes glycoproteins when they are incompletely folded. Calnexin associates with numerous oligomeric protein complexes within the ER, including beta1 and alpha6 integrins (5), major histocompatibility class I (6, 7) and class II molecules (8), the antigen receptors expressed on T and B lymphocytes (7), human thyroperoxidase (hTPO) (9), and acetylcholine receptor (10). Recent data also suggest that calnexin might be responsible for the prolonged retention of pro-alpha6 integrin within ER compartment (11). Furthermore, calnexin has been demonstrated to function as a bonafide molecular chaperone capable of interacting with polypeptide segments of folding glycoproteins (12).
Catalog #C1035-26C
ApplicationsWestern Blot (Colorimetric) (1): 1:2,000
Immunoprecipitation (1): 1:100
Immunocytochemistry (3): 1:200
Optimal dilutions to be determined by researcher.
Positive ControlsHeat Shocked HeLa Cell Lysate
Clone TypePolyclonal
HostRabbit
SourceCanine
FormSerum
PuritySerum
ImmunogenA 19 residue synthetic peptide DTSAPTSPKVTYKAPVPSG based on the canine calnexin (residues 50-68) (2) and the peptide coupled to KLH.
SpecificityAntibody is raised against a synthetic peptide from the amino terminus of canine calnexin and exhibits cross-reactivity with human, monkey, mouse, rat, rabbit, guinea pig, hamster, bovine, canine, sheep, chicken, porcine, chinook salmon and Xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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